PE was excluded if the YEARS criteria was 0 and D-dimer <1000 or the YEARS criteria was 1 and D-dimer <500. Prospective, multicenter cohort study including 3,616 consecutive patients with suspected pulmonary embolism combined use of the YEARS criteria (clinical signs of DVT, hemoptysis, and whether PE was the most likely diagnosis) with D-dimer. Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study. Van der Hulle T, Cheung WY, Kooij S, et al. The study utilized 6 different assays and it is unclear whether the variability in the proportion of patients with negative results was due to assay characteristics vs. The age-adjusted cut point increased the proportion of negative d-dimer studies by 12%. Among 337 patients with d-dimer levels above the standard cut-off of 500 mcg/L but below their age-adjusted cut-off in whom treatment was withheld, 0.3% had a DVT or PE during the ensuing 3 months. This study explored the reliability of using a higher normal cut-off d-dimer level for patients > 50 years old with low clinical probability of PE (age-adjusted d-dimer level = patient age x 10). Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. Righini M, Van Es J, Den Exter PL, et al. Algorithms for Diagnosis of Suspected Pulmonary Embolism
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